© 1990 Medical Council on Alcoholism GENOTYPING STUDY OF ALCOHOL DEHYDROGENASE CLASS I POLYMORPHISM IN FRENCH PATIENTS WITH ALCOHOLIC

Abstract — Comparison of alcohol dehydrogenase polymorphism at the loci ADH, and ADH3 is made in France between 46 alcoholic cirrhotic patients and 39 controls, by genotyping technique using polymerase chain reaction on blood microsample collected on blotting paper. The genotype distributions are similar, with low frequency of the ADH22 allele. Polymorphism at the ADH3 locus is not a genetic factor for alcoholic cirrhosis in France