Open Access Usefulness of 11C-Methionine Positron Emission Tomography in Differential Diagnosis between Recurrent Tumours and Radiation Necro- sis in Patients with Glioma: An Overview

Abstract: Differential diagnosis between radiation necrosis and tumour recurrence is important in the clinical manage-ment of patients with glioma. We performed an overview of the literature in order to summarize the role of 11C-methionine positron emission tomography (MET-PET) in this setting. This functional imaging method appears to have a high sensitivity, specificity, and accuracy in differentiating between glioma recurrence and radiation necrosis. Neverthe-less, possible false negative and false positive results of MET-PET should be well kept in mind in the management of pa-tients with glioma