Original Article Large Volume Autologous Plasma Predonation and Retransfusion in Orthopedic Surgical Patients

Abstract Background: Intraoperative washed autologous transfusion of the scavenged blood can reduce the deterioration of anemia, even during the operation with a comparatively large blood loss. On the other hand, plasma level can not be collected by this system. The preoperative donation and perioperative retransfusion of autologous plasma may reduce the plasma dilution. Purpose: The influence of a large volume plasma predonation and perioperative retransfusion on the plasma protein level was investigated. Methods: Thirteen patients (63.2 ± 13.2 yr, 70.3 ± 12.1 kg) were examined regarding their serum protein (SP), IgG, coagulation systems, colloid osmotic pressure (COP), blood cell count before, just after, 2 h after and 7 days after the donation of 900 ml plasma by plasmapheresiswith a simultaneous volume replacement. Twenty surgical patients (52.8 ± 17.3 yr, 72.6 ± 16.6 kg, the mean predonated autologous plasma: 2100 ml) with intra- and postoperative retransfusion of autologous plasma were examined perioperatively for SP, IgG, coagulation systems and COP. These parameters were compared with that of the predonated plasma. Results: All data including SP, coagulation and COP,with the exception of IgG, completely recoveredwithin 7 days after preoperative plasmapheresis. Perioperatively, autologous washed blood transfusion system was used. The retransfused volume of autologous predonated plasma was 1740 ml on average. Although about 4 l o