An Inbred Line of Transgenic Mice Expressing an Internally Deleted Gene for Type 11 Procollagen (COL2A1) Young Mice Have a Variable Phenotype of a Chondrodysplasia and Older Mice Have Osteoarthritic Changes in Joints

A mutation of the Col2a1 gene (G1170S) alters the transgenic murine phenotype and cartilage matrix homeostasis

Yang, Ruei-Cheng
Chen, Ming-Hong
Chen, Pei-Yu
Chen, Ching-Yun
Tsai, Shih-Feng
Cheng, Cheng-Kung
Sun, Jui-Sheng

November 2014

Background/PurposeGenomic studies have revealed that there is a significant association between a po...

Osteoarthritis-like lesions in transgenic mice harboring a small deletion mutation in type II collagen gene

Säämänen, A.-M.K
Salminen, H.J
Dean, P.B
De Crombrugghe, B
Vuorio, E.I
Metsäranta, M.P.H

July 2000

AbstractObjective The present study was conducted on transgenic Del1 (+/−) mice harboring six copies...

Generation of Col2a1-ccn2 transgenic mice.

Nao Tomita (395624)
Takako Hattori (395625)
Shinsuke Itoh (125939)
Eriko Aoyama (395626)
Mayumi Yao (395627)
Takashi Yamashiro (395628)
Masaharu Takigawa (58830)

March 2013

(A) Schematic representation of the construct of the expression of HA-tagged CCN2 and IRES-LacZ i...

Depletion of cartilage collagen fibrils in mice carrying a dominant negative Col2a1 transgene affects chondrocyte differentiation.

Ottavia Barbieri
Simonetta Astigiano
Monica Morini
Sara Tavella
Anna Schito
Alessandro Corsi
Davide Di Martino
Paolo Bianco
Ranieri Cancedda
Silvio Garofalo

January 2003

We have generated transgenic mice harboring the deletion of exon 48 in the mouse α1(II) procollagen ...

Depletion of cartilage collagen fibrils in mice carrying a dominant negative Col2a1 transgene affects chondrocyte differentiation.

Barbieri, Ottavia
Astigiano, Simonetta
Morini, Monica
Tavella, Sara
Schito, ANNA MARIA
Corsi, Alessandro
Di Martino, Davide
Bianco, Paolo
Cancedda, Ranieri
Garofalo, Silvio

January 2003

We have generated transgenic mice harboring the deletion of exon 48 in the mouse \u3b11(II) procolla...

Depletion of cartilage collagen fibrils in mice carrying a dominant negative col2a1 transgene affects chondrocyte differentiation.

Barbieri, O
Astigiano, S
Morini, M
Tavella, S
Schito, A
Corsi, Alessandro
DI MARTINO, D
Bianco, Paolo
Cancedda, R.
Garofalo, S.

January 2003

We have generated transgenic mice harboring the deletion of exon 48 in the mouse alpha1(II) procolla...

A mutation of the Col2a1 gene (G1170S) alters the transgenic murine phenotype and cartilage matrix homeostasis

Yang, Ruei-Cheng
Chen, Ming-Hong
Chen, Pei-Yu
Chen, Ching-Yun
Tsai, Shih-Feng
Cheng, Cheng-Kung
Sun, Jui-Sheng

November 2014

Background/PurposeGenomic studies have revealed that there is a significant association between a po...

A mutation of the Col2alpha1 gene (G1170S) alters the transgenic murine phenotype and cartilage matrix homeostasis

Yang, RC

[[abstract]]Background/Purpose Genomic studies have revealed that there is a significant association...

Osteoarthritis-like lesions in transgenic mice harboring a small deletion mutation in type II collagen gene

Säämänen, A.-M.K
Salminen, H.J
Dean, P.B
De Crombrugghe, B
Vuorio, E.I
Metsäranta, M.P.H

July 2000

AbstractObjective The present study was conducted on transgenic Del1 (+/−) mice harboring six copies...

A mutation of the Col2alpha1 gene (G1170S) alters the transgenic murine phenotype and cartilage matrix homeostasis

Yang, RC

[[abstract]]Background/Purpose Genomic studies have revealed that there is a significant association...

Abnormal chondrocyte differentiation and chondrodysplasia in transgenic mice

Kuffner, T
Cheah, KSE
Trainor, PA
Levy, A
Wai, AWK
Tam, PPL

January 1994

Conference abstract (Session 4: Expression of normal and mutated genes in cells and men 2. Type II c...

Phenotypic variability and incomplete penetrance of spontaneous fractures in an inbred strain of transgenic mice expressing a mutated collagen gene (COL1A1

Ruth Pereira
Kenneth Halford
Boris P. Sokolov
Jaspal S. Khillan
Darwin J. Prockop

January 1994

Phenotype variability and incomplete penetrance are fre-quently observed in human monogenic diseases...

A mutation of the Col2a1 gene (G1170S) alters the transgenic murine phenotype and cartilage matrix homeostasis

Yang, Ruei-Cheng
孫瑞昇

June 2017

Background/Purpose: Genomic studies have revealed that there is a significant association between a ...

Cloning and characterization of the murinecol11a2 gene, itscDNA, and its functional analysis in transgenic mice

Vandenberg, Philipp

January 1995

To begin to investigate the role of the cartilage-specific expressed alpha-2 (XI) chain, cosmid clon...

Transgenic expression of the p.Val883Met mutant in chondrocytes reproduced the patients’ phenotype in mice.

Kohji Miura (312586)
Noriyuki Namba (312587)
Makoto Fujiwara (312588)
Yasuhisa Ohata (312589)
Hidekazu Ishida (312590)
Taichi Kitaoka (312591)
Takuo Kubota (312592)
Haruhiko Hirai (312593)
Chikahisa Higuchi (312594)
Noriyuki Tsumaki (162094)
Hideki Yoshikawa (10499)
Norio Sakai (185474)
Toshimi Michigami (312595)
Keiichi Ozono (312596)

February 2013

(A) Radiographs of transgenic founder No. 4 expressing the p.Val883Met mutant NPR2 with th...

A mutation of the Col2a1 gene (G1170S) alters the transgenic murine phenotype and cartilage matrix homeostasis

Yang, Ruei-Cheng
Chen, Ming-Hong
Chen, Pei-Yu
Chen, Ching-Yun
Tsai, Shih-Feng
Cheng, Cheng-Kung
Sun, Jui-Sheng

November 2014

Background/PurposeGenomic studies have revealed that there is a significant association between a po...

Osteoarthritis-like lesions in transgenic mice harboring a small deletion mutation in type II collagen gene

Säämänen, A.-M.K
Salminen, H.J
Dean, P.B
De Crombrugghe, B
Vuorio, E.I
Metsäranta, M.P.H

July 2000

AbstractObjective The present study was conducted on transgenic Del1 (+/−) mice harboring six copies...

Generation of Col2a1-ccn2 transgenic mice.

Nao Tomita (395624)
Takako Hattori (395625)
Shinsuke Itoh (125939)
Eriko Aoyama (395626)
Mayumi Yao (395627)
Takashi Yamashiro (395628)
Masaharu Takigawa (58830)

March 2013

(A) Schematic representation of the construct of the expression of HA-tagged CCN2 and IRES-LacZ i...

Depletion of cartilage collagen fibrils in mice carrying a dominant negative Col2a1 transgene affects chondrocyte differentiation.

Ottavia Barbieri
Simonetta Astigiano
Monica Morini
Sara Tavella
Anna Schito
Alessandro Corsi
Davide Di Martino
Paolo Bianco
Ranieri Cancedda
Silvio Garofalo

January 2003

We have generated transgenic mice harboring the deletion of exon 48 in the mouse α1(II) procollagen ...

Depletion of cartilage collagen fibrils in mice carrying a dominant negative Col2a1 transgene affects chondrocyte differentiation.

Barbieri, Ottavia
Astigiano, Simonetta
Morini, Monica
Tavella, Sara
Schito, ANNA MARIA
Corsi, Alessandro
Di Martino, Davide
Bianco, Paolo
Cancedda, Ranieri
Garofalo, Silvio

January 2003

We have generated transgenic mice harboring the deletion of exon 48 in the mouse \u3b11(II) procolla...

Depletion of cartilage collagen fibrils in mice carrying a dominant negative col2a1 transgene affects chondrocyte differentiation.

Barbieri, O
Astigiano, S
Morini, M
Tavella, S
Schito, A
Corsi, Alessandro
DI MARTINO, D
Bianco, Paolo
Cancedda, R.
Garofalo, S.

January 2003

We have generated transgenic mice harboring the deletion of exon 48 in the mouse alpha1(II) procolla...

A mutation of the Col2a1 gene (G1170S) alters the transgenic murine phenotype and cartilage matrix homeostasis

Yang, Ruei-Cheng
Chen, Ming-Hong
Chen, Pei-Yu
Chen, Ching-Yun
Tsai, Shih-Feng
Cheng, Cheng-Kung
Sun, Jui-Sheng

November 2014

Background/PurposeGenomic studies have revealed that there is a significant association between a po...

A mutation of the Col2alpha1 gene (G1170S) alters the transgenic murine phenotype and cartilage matrix homeostasis

Yang, RC

[[abstract]]Background/Purpose Genomic studies have revealed that there is a significant association...

Osteoarthritis-like lesions in transgenic mice harboring a small deletion mutation in type II collagen gene

Säämänen, A.-M.K
Salminen, H.J
Dean, P.B
De Crombrugghe, B
Vuorio, E.I
Metsäranta, M.P.H

July 2000

AbstractObjective The present study was conducted on transgenic Del1 (+/−) mice harboring six copies...

A mutation of the Col2alpha1 gene (G1170S) alters the transgenic murine phenotype and cartilage matrix homeostasis

Yang, RC

[[abstract]]Background/Purpose Genomic studies have revealed that there is a significant association...

Abnormal chondrocyte differentiation and chondrodysplasia in transgenic mice

Kuffner, T
Cheah, KSE
Trainor, PA
Levy, A
Wai, AWK
Tam, PPL

January 1994

Conference abstract (Session 4: Expression of normal and mutated genes in cells and men 2. Type II c...

Phenotypic variability and incomplete penetrance of spontaneous fractures in an inbred strain of transgenic mice expressing a mutated collagen gene (COL1A1

Ruth Pereira
Kenneth Halford
Boris P. Sokolov
Jaspal S. Khillan
Darwin J. Prockop

January 1994

Phenotype variability and incomplete penetrance are fre-quently observed in human monogenic diseases...

A mutation of the Col2a1 gene (G1170S) alters the transgenic murine phenotype and cartilage matrix homeostasis

Yang, Ruei-Cheng
孫瑞昇

June 2017

Background/Purpose: Genomic studies have revealed that there is a significant association between a ...

Cloning and characterization of the murinecol11a2 gene, itscDNA, and its functional analysis in transgenic mice

Vandenberg, Philipp

January 1995

To begin to investigate the role of the cartilage-specific expressed alpha-2 (XI) chain, cosmid clon...

Transgenic expression of the p.Val883Met mutant in chondrocytes reproduced the patients’ phenotype in mice.

Kohji Miura (312586)
Noriyuki Namba (312587)
Makoto Fujiwara (312588)
Yasuhisa Ohata (312589)
Hidekazu Ishida (312590)
Taichi Kitaoka (312591)
Takuo Kubota (312592)
Haruhiko Hirai (312593)
Chikahisa Higuchi (312594)
Noriyuki Tsumaki (162094)
Hideki Yoshikawa (10499)
Norio Sakai (185474)
Toshimi Michigami (312595)
Keiichi Ozono (312596)

February 2013

(A) Radiographs of transgenic founder No. 4 expressing the p.Val883Met mutant NPR2 with th...

A mutation of the Col2a1 gene (G1170S) alters the transgenic murine phenotype and cartilage matrix homeostasis

Yang, Ruei-Cheng
Chen, Ming-Hong
Chen, Pei-Yu
Chen, Ching-Yun
Tsai, Shih-Feng
Cheng, Cheng-Kung
Sun, Jui-Sheng

November 2014

Background/PurposeGenomic studies have revealed that there is a significant association between a po...

Osteoarthritis-like lesions in transgenic mice harboring a small deletion mutation in type II collagen gene

Säämänen, A.-M.K
Salminen, H.J
Dean, P.B
De Crombrugghe, B
Vuorio, E.I
Metsäranta, M.P.H

July 2000

AbstractObjective The present study was conducted on transgenic Del1 (+/−) mice harboring six copies...

Generation of Col2a1-ccn2 transgenic mice.

Nao Tomita (395624)
Takako Hattori (395625)
Shinsuke Itoh (125939)
Eriko Aoyama (395626)
Mayumi Yao (395627)
Takashi Yamashiro (395628)
Masaharu Takigawa (58830)

March 2013

(A) Schematic representation of the construct of the expression of HA-tagged CCN2 and IRES-LacZ i...

An Inbred Line of Transgenic Mice Expressing an Internally Deleted Gene for Type 11 Procollagen (COL2A1) Young Mice Have a Variable Phenotype of a Chondrodysplasia and Older Mice Have Osteoarthritic Changes in Joints

Abstract

Extracted data

An Inbred Line of Transgenic Mice Expressing an Internally Deleted Gene for Type 11 Procollagen (COL2A1) Young Mice Have a Variable Phenotype of a Chondrodysplasia and Older Mice Have Osteoarthritic Changes in Joints

Abstract

Extracted data

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