72 Posters EMBnet.journal 19.A REDITOOLS: efficient RNA editing detection by RNA-SEQ data

RNA editing and alternative splicing are post-transcriptional modifications that increase the complexity of eukaryotic transcriptomes and proteomes. Both phenomena have been effi-ciently investigated by massive sequencing ac-cording to recent high-throughput technologies. In particular, the RNA-seq methodology is the de facto technology to investigate entire eukaryotic RNA populations at single nucleotide level pro-viding fruitful snapshots of cell/tissue activities in a variety of normal and non-homeostatic condi-tions (Wang, et al., 2009). RNA editing can modify specific RNAs at se-lected locations (Maas, 2011) and, in human, fre-quently involves the deamination of adenosine