Changes in myocyte cell shape and tissue structure are concurrent with changes in electromechanical function in both the developing and diseased heart. While the anisotropic architecture of cardiac tissue is known to influence the propagation of the action potential, the influence of tissue architecture and its potential role in regulating excitation–contraction coupling (ECC) are less well defined. We hypothesized that changes in the shape and the orientation of cardiac myocytes induced by spatial arrangement of the extracellular matrix (ECM) affects ECC. To test this hypothesis, we isolated and cultured neonatal rat ventricular cardiac myocytes on various micropatterns of fibronectin where they self-organized into tissues with varying deg...
The heart actively remodels architecture in response to various physiological and pathological condi...
The development of cardiac models that faithfully recapitulate heart conditions is the goal of cardi...
Cardiac electrical excitation-propagation is influenced by myocyte orientations (cellular organizati...
Changes in myocyte cell shape and tissue structure are concurrent with changes in electromechanical ...
<p>The heart is a muscular organ with a wrapping, laminar structure embedded with neural and vascula...
In the cardiac microenvironment, cardiomyocytes (CMs) are embedded in an aligned and structured extr...
Regenerative cardiac tissue is a promising field of study with translational potential as a therapeu...
In vitro studies of cardiac physiology and drug response have traditionally been performed on i...
The myocardium is a mechanically active tissue typified by anisotropy of the resident cells [cardiom...
<p>The role of cardiac tissue structure in both normal and abnormal impulse conduction has been exte...
The heart has a dynamic mechanical environment contributed by its unique cellular composition and th...
International audienceDue to structural heterogeneities within the tissue, the myocardium displays a...
Abstract—Structural and functional cardiac anisotropy varies with the development, location, and pat...
The heart is a complex organ whose structure and function are intricately linked at multiple length ...
The heart is a vital organ that pumps blood throughout the body by constantly, cyclically contractin...
The heart actively remodels architecture in response to various physiological and pathological condi...
The development of cardiac models that faithfully recapitulate heart conditions is the goal of cardi...
Cardiac electrical excitation-propagation is influenced by myocyte orientations (cellular organizati...
Changes in myocyte cell shape and tissue structure are concurrent with changes in electromechanical ...
<p>The heart is a muscular organ with a wrapping, laminar structure embedded with neural and vascula...
In the cardiac microenvironment, cardiomyocytes (CMs) are embedded in an aligned and structured extr...
Regenerative cardiac tissue is a promising field of study with translational potential as a therapeu...
In vitro studies of cardiac physiology and drug response have traditionally been performed on i...
The myocardium is a mechanically active tissue typified by anisotropy of the resident cells [cardiom...
<p>The role of cardiac tissue structure in both normal and abnormal impulse conduction has been exte...
The heart has a dynamic mechanical environment contributed by its unique cellular composition and th...
International audienceDue to structural heterogeneities within the tissue, the myocardium displays a...
Abstract—Structural and functional cardiac anisotropy varies with the development, location, and pat...
The heart is a complex organ whose structure and function are intricately linked at multiple length ...
The heart is a vital organ that pumps blood throughout the body by constantly, cyclically contractin...
The heart actively remodels architecture in response to various physiological and pathological condi...
The development of cardiac models that faithfully recapitulate heart conditions is the goal of cardi...
Cardiac electrical excitation-propagation is influenced by myocyte orientations (cellular organizati...