tion motif (ITAM)–containing proteins have recently been demonstrated in mac-rophages and neutrophils to be required for cell surface integrins to transmit acti-vation signals into the cell. To identify ITAM-bearing proteins that mediate signal-ing via the platelet-specific integrinIIb3, fibrinogen binding was induced by (1) al-lowing platelets to spread directly on immobilized fibrinogen, or (2) activating the PAR1 thrombin receptor on platelets in suspension. Both initiated strong, li-gand binding–dependent tyrosine phos-phorylation of the ITAM-bearing platelet Fc receptor, FcRIIa, as well as down-stream phosphorylation of the protein tyrosine kinase Syk and activation of phospholipase C2 (PLC2). Addition of Fab fragments of an FcRIIa-spe...
Filamin A (FlnA) cross-links actin filaments and connects the Von Willebrand factor receptor GPIb-IX...
Collagen binding to glycoprotein VI (GPVI) induces signals critical for platelet activation in throm...
pp72syk is essential for development and function of several hematopoietic cells, and it becomes act...
Previous studies have implicated the immunoglobulin (Ig)-immunoreceptor tyrosine-based inhibitory mo...
Platelets are well-known for their critical role in hemostasis, i.e. the prevention of blood loss at...
Platelets are well-known for their critical role in hemostasis, i.e. the prevention of blood loss at...
abstract: Platelets are specialized blood cells that play crucial role in normal physiologic and pat...
© 2015 International Society on Thrombosis and Haemostasis. Beyond their prominent role in hemostasi...
© 2015 International Society on Thrombosis and Haemostasis. Beyond their prominent role in hemostasi...
<div><p>IgG immune complexes contribute to the etiology and pathogenesis of numerous autoimmune diso...
IgG immune complexes contribute to the etiology and pathogenesis of numerous autoimmune disorders, i...
Background: The main role of platelets is to control haemostasis when there is a blood vessel injury...
Abstract Integrins are a family of transmembrane glycoprotein signaling receptors that can transmit ...
Platelets play a critical role in maintaining vascular integrity during inflammation, but little is ...
Platelets play a critical role in maintaining vascular integrity during inflammation, but little is ...
Filamin A (FlnA) cross-links actin filaments and connects the Von Willebrand factor receptor GPIb-IX...
Collagen binding to glycoprotein VI (GPVI) induces signals critical for platelet activation in throm...
pp72syk is essential for development and function of several hematopoietic cells, and it becomes act...
Previous studies have implicated the immunoglobulin (Ig)-immunoreceptor tyrosine-based inhibitory mo...
Platelets are well-known for their critical role in hemostasis, i.e. the prevention of blood loss at...
Platelets are well-known for their critical role in hemostasis, i.e. the prevention of blood loss at...
abstract: Platelets are specialized blood cells that play crucial role in normal physiologic and pat...
© 2015 International Society on Thrombosis and Haemostasis. Beyond their prominent role in hemostasi...
© 2015 International Society on Thrombosis and Haemostasis. Beyond their prominent role in hemostasi...
<div><p>IgG immune complexes contribute to the etiology and pathogenesis of numerous autoimmune diso...
IgG immune complexes contribute to the etiology and pathogenesis of numerous autoimmune disorders, i...
Background: The main role of platelets is to control haemostasis when there is a blood vessel injury...
Abstract Integrins are a family of transmembrane glycoprotein signaling receptors that can transmit ...
Platelets play a critical role in maintaining vascular integrity during inflammation, but little is ...
Platelets play a critical role in maintaining vascular integrity during inflammation, but little is ...
Filamin A (FlnA) cross-links actin filaments and connects the Von Willebrand factor receptor GPIb-IX...
Collagen binding to glycoprotein VI (GPVI) induces signals critical for platelet activation in throm...
pp72syk is essential for development and function of several hematopoietic cells, and it becomes act...