Original article Second cancer after the treatment for Hodgkin's disease: A report from the International Database on Hodgkin's Disease

Summary. Twenty institutions/cooperative groups tabulat-ed second cancers among 12,411 patients diagnosed with Hodgkin's disease between 1960 and 1987, giving 82,850 person-years of observation. Overall, 631 second cancers were observed, as compared with 223.25 expected (observed (O) to expected (E) ratio 2.83, p<0.001) at least one year after the diagnosis of Hodgkin's disease. Second cancers were acute leukaemias (A_L) in 158 cases as compared with 5.75 expected (O/E = 27.48, p< 0.001), non-Hodgkin's lym-phomas (NHL) in 106 cases as compared with 3.34 expect-ed (O/E- 31.77, p< 0.001), and solid tumors (ST) in 367 cases as compared with 214.16 expected (O/E — 1.71, p<0.001), with no differences between males and females. Excess of ST was observed for the following anatomic sites: salivary gland, small intestine, colon, bronchus, pleura, bone