1IRCCS Casa Sollievo della Sofferenza, Clinical Unit of

Background. In Mexican Americans, the IRS1 G972R poly-morphism (rs1801278) has been associated to such a marked reduction in glomerular filtration rate (GFR) (i.e. β =−8.3 mL/ min/1.73 m2) to be considered a major determinant of kidney function. Methods. This was a cross-sectional study to investigate whether a similarly strong effect can also be observed among individuals of European ancestry. We investigated a total of 3973 White patients with type 2 diabetes. Standardized serum creatinine was measured by the modified kinetic Jaffè reaction and estimated GFR (eGFR) calculated by the modification diet renal disease (MDRD) formula; rs1801278 was genotyped by TaqMan assay. Results. No significant association was observed, with R97