Utilizing the bioassay of Sayers, Sayers and Woodbury (1), based upon adrenal ascorbic acid depletion in the hypophysectomized rat, Paris (2), Taylor (3), and Sydnor (4, 5) and their co-work-ers, were unable to find detectable levels of ACTH in normal subjects. Gaarenstroom and his col-leagues (6) observed detectable quantities in 7 of 33 normal subjects. Others (7-12) have reported very high concentrations. Sayers (13) discounted these latter reports as being inconsistent with the observation (14) that ACTH causes a maximal adrenal response in doses calculated to give much lower plasma concentrations. He concluded that the normal concentration is less than 0.5 mU per 100 ml of blood. Fujita (15) concluded from his studies that the normal c...
In the present study, the minimum level of plasma ACTH to maintain normal adrenocortical function (c...
The output of estrogens, testosterone and their precursors was compared with that of glucocorticoste...
Objective: The intravenous low‐dose ACTH test has been proposed as a sensitive tool to assess adrena...
This assay was based on the corticosterone response to the intravenous administration of ACTH in 4 h...
Adrenocorticotrophin (ACTH) is formed from the cleavage of pro-opiomelanocortin. Measurement of plas...
Several workers (Greenspan et al., 1950; Reinhardt and Li, 1951; Stack-Dunne and Young, 1951) have r...
The concentration of adrenocorticotrophic hormone in the blood of rats was estimated at various time...
The depressant effect of adrenal steroids on the release of pituitary adrenocorticotrophic hormone (...
We used ELISA to measure (A) corticosterone and (B) adrenocorticotropic hormone (ACTH) in the serum ...
The trophic action of ACTH was investigated in intact rats by selective neutralization of endogenous...
In addition to the in-vivo studies on the feedback regulation of the hypothalamic-hypophysial\x=req-...
The recognition of the important role played by the adrenal cortex in normal physiology and its sign...
The response of the adrenal cortex to exogenous ACTH has been recognized as one of the more specific...
Both ACTH and NPS-ACTH in which the single tryptophan residue of the hormone is modified were able t...
Studies on the adrenal cortex began with the demonstration that it is essential for life. The next...
In the present study, the minimum level of plasma ACTH to maintain normal adrenocortical function (c...
The output of estrogens, testosterone and their precursors was compared with that of glucocorticoste...
Objective: The intravenous low‐dose ACTH test has been proposed as a sensitive tool to assess adrena...
This assay was based on the corticosterone response to the intravenous administration of ACTH in 4 h...
Adrenocorticotrophin (ACTH) is formed from the cleavage of pro-opiomelanocortin. Measurement of plas...
Several workers (Greenspan et al., 1950; Reinhardt and Li, 1951; Stack-Dunne and Young, 1951) have r...
The concentration of adrenocorticotrophic hormone in the blood of rats was estimated at various time...
The depressant effect of adrenal steroids on the release of pituitary adrenocorticotrophic hormone (...
We used ELISA to measure (A) corticosterone and (B) adrenocorticotropic hormone (ACTH) in the serum ...
The trophic action of ACTH was investigated in intact rats by selective neutralization of endogenous...
In addition to the in-vivo studies on the feedback regulation of the hypothalamic-hypophysial\x=req-...
The recognition of the important role played by the adrenal cortex in normal physiology and its sign...
The response of the adrenal cortex to exogenous ACTH has been recognized as one of the more specific...
Both ACTH and NPS-ACTH in which the single tryptophan residue of the hormone is modified were able t...
Studies on the adrenal cortex began with the demonstration that it is essential for life. The next...
In the present study, the minimum level of plasma ACTH to maintain normal adrenocortical function (c...
The output of estrogens, testosterone and their precursors was compared with that of glucocorticoste...
Objective: The intravenous low‐dose ACTH test has been proposed as a sensitive tool to assess adrena...