Coronary Artery Disease in Koreans

Background and Objectives：Little is known about the relationship between the apolipoprotein (apo) B-100, or the apo B-100/apo A-I ratio, and coronary artery disease (CAD). The aim of this study was to investigate this association. Subjects and Methods：Our study was carried out on 194 patients who had undergone elective coronary angiography (CAG), but had received no lipid-lowering medication. Patients with acute myocardial infarction were excluded. Stenosis of ≥50 % in 1 or more coronary arteries was classified as CAD (+). Results：HDL-C and apo A-I were significantly higher in females than in males (p＝0.009 and 0.036). In our population we found that the apo A-I, HDL-C and the apo B-100/apo A-I ratio were significantly related to CAD (p＝0.001, 0.006, and 0.007 respectively). In the male group (n＝111), the apo B-100/apo A-I ratio was the only parameter statistically significant to CAD after correcting for age, diabetes mellitus and hypertension. Whereas, in the female group (n＝83), the apo B/apo A-I ratio, apo B-100/apo A-I ratio, apo B-100, nonHDL-C, triglyceride, apo B, total cholesterol and low-density lipoprotein cholesterol were al