Annals of Internal Medicine Long-Term Treatment with Omeprazole for Refractory

• Objective: To evaluate the long-term efficacy and safety of omeprazole in patients with gastroesophageal reflux disease resistant to treatment with histamine-2 (H2)-receptor antagonists. • Design: Cohort analytic study with a mean follow-up of 48 months (range, 36 to 64 months). • Setting: Patients receiving ambulatory care from referral centers. • Patients: 91 patients with gastroesophageal reflux disease resistant to treatment with an H2-receptor antagonist but subsequently responsive to 40 mg of omeprazole daily. • Intervention: Open maintenance therapy consisting of 20 mg of omeprazole daily in 86 patients and 40 m