FLOW INJECTION DETERMINATION OF SALBUTAMOL USING A SOLID- PHASE REACTOR CONTAINING LEAD (IV) DIOXIDE IMMOBILIZED

This article is available online at www.ssjournals.com A simple, sensitive and fast continuous flow injection system with spectrophotometric detection was proposed for the determination of salbutamol sulphate (SAL) in pharmaceutical formulations using a solid-phase reactor containing PbO2 immobilized in a polymeric matrix. The method was based on oxidation of the reagent (N, N-dimethyl-p-phenelynediamine) with PbO2 producing dimethylbenzoquinone diimine, which is then coupled with SAL in alkaline medium. The blue colored product was monitored at 640 nm. The calibration graph was linear over the range 0.5 to 60 µg mL-1 with a relative standard deviation less than 3.8 % (n=33) and sample throughput 60 samples per hour. Solid-phase reactors can be applied to the determination of SAL in a flow injection system with high sensitivity and significant advantages over conventional procedures