Abstract The science of wildlife fertility control originated in the mid-twentieth century, out of a growing need for alternatives to lethal controls for selected wildlife populations, where traditional lethal controls were no longer legal, wise, safe or publicly acceptable. Until late in the century the science was uncoordinated and without significant funding or cooperation among investigators. A 25-year conference series brought scientists engaged in this endeavor together, from around the world and set the stage for more rapid development and research support. In rapid fashion, steroid related efforts gave way to contraceptive vaccines and gonadotropic-releasing hormone (GnRH) agonists and by the turn of century actual successful manage...