Background: There are unpredictable inter-individual differences in sensitivity to psoralen-UVA (PUVA) photochemother-apy, used to treat skin diseases including psoriasis. Psoralens are metabolised by cytochrome P450 enzymes (P450), and we hypothesised that variability in cutaneous P450 expression may influence PUVA sensitivity. We previously showed that P450 CYP1B1 was abundantly expressed in human skin and regulated by PUVA, and described marked inter-individual differences in cutaneous CYP1B1 expression. Objectives: We investigated whether CYP1B1 made a significant contribution to 8-methoxypsoralen (8-MOP) metabolism, and whether individuality in CYP1B1 activity influenced PUVA sensitivity. Methods: We used E. coli membranes co-expressin...
expression. activity influenced PUVA sensitivity.-expressing mammalian cells to assess PUVA sensiti...
International audienceBackground & Aims: Cytochrome P450 1A1 catalyzes the degradation of endobiotic...
The human cytochrome P450 (CYP) family of monooxygenases is important for metabolism of drugs and en...
Background:There are unpredictable inter-individual differences in sensitivity to psoralen-UVA (PUVA...
There are unpredictable inter-individual differences in sensitivity to psoralen-UVA (PUVA) photochem...
Background: There are unpredictable inter-individual differences in sensitivity to psoralen-UVA (PUV...
Background Treatment of common skin diseases such as psoriasis is complicated by differences between...
Psoralens are tricyclic furocoumarins with potent photosensitizing properties in the skin and are no...
Summary Background There is marked interpatient variation in responses to psoralen-ultraviolet A (PU...
Cytochrome P450 drug metabolizing enzymes are implicated in personalized medicine for two main reaso...
expression. activity influenced PUVA sensitivity.-expressing mammalian cells to assess PUVA sensiti...
International audienceBackground & Aims: Cytochrome P450 1A1 catalyzes the degradation of endobiotic...
The human cytochrome P450 (CYP) family of monooxygenases is important for metabolism of drugs and en...
Background:There are unpredictable inter-individual differences in sensitivity to psoralen-UVA (PUVA...
There are unpredictable inter-individual differences in sensitivity to psoralen-UVA (PUVA) photochem...
Background: There are unpredictable inter-individual differences in sensitivity to psoralen-UVA (PUV...
Background Treatment of common skin diseases such as psoriasis is complicated by differences between...
Psoralens are tricyclic furocoumarins with potent photosensitizing properties in the skin and are no...
Summary Background There is marked interpatient variation in responses to psoralen-ultraviolet A (PU...
Cytochrome P450 drug metabolizing enzymes are implicated in personalized medicine for two main reaso...
expression. activity influenced PUVA sensitivity.-expressing mammalian cells to assess PUVA sensiti...
International audienceBackground & Aims: Cytochrome P450 1A1 catalyzes the degradation of endobiotic...
The human cytochrome P450 (CYP) family of monooxygenases is important for metabolism of drugs and en...