Vibrio cholerae strains of the classical biotype express the genes encoding cholera toxin (CT) and toxin-coregulated pilus (TCP) under a variety of environmental conditions in vitro, whereas El Tor biotype strains express these genes only under specialized culture conditions. We show here that a single base-pair difference at positions 265 and 266 of the classical and El Tor tcpPH promoters, respectively, is responsible for the differential regulation of virulence gene expression in these two disease-causing biotypes. Analysis of tcpP-lacZ fusions in both V. cholerae and Escherichia coli indicated that transcriptional activation of the El Tor tcpPH promoter by the LysR regulator AphB was significantly reduced relative to that of the classic...
Coordinate expression of many virulence genes in the human pathogen Vibrio cholerae is controlled by...
Co-ordinate expression of many virulence genes in the human pathogen Vibrio cholerae is under the di...
Microbes are often underestimated for the flexibility and subtlety by which they can regulate their ...
We describe here a new member of the LysR family of transcriptional regulators, AphB, which is requi...
Expression of genes encoding the toxin-co-regulated pilus (TCP) varies between the two biotypes of V...
Epidemic strains of Vibrio cholerae O1 are divided into two biotypes, classical and El Tor. In both ...
Epidemic strains of Vibrio cholerae O1 are divided into two biotypes, classical and El Tor. In both ...
A physical map has been constructed of the 5-kb XbaI fragment encoding the promoter proximal of regi...
Vibrio cholerae is the agent of the severe diarrheal disease cholera, and it perpetuates in aquatic ...
The two major disease-causing biotypes of Vibrio cholerae, classical and El Tor, exhibit differences...
Insertion mutations in two Vibrio cholerae genes, cya and crp, which encode adenylate cyclase and th...
AbstractThe temporal expression patterns of the critical Vibrio cholerae virulence genes, tcpA and c...
The virulence of a pathogen is dependent on a discrete set of genetic determinants and their well-re...
The aim of this work was to analyze the relationship between cellular localization and function of T...
ABSTRACT Vibrio cholerae is the etiological agent of the infectious disease cholera, which is charac...
Coordinate expression of many virulence genes in the human pathogen Vibrio cholerae is controlled by...
Co-ordinate expression of many virulence genes in the human pathogen Vibrio cholerae is under the di...
Microbes are often underestimated for the flexibility and subtlety by which they can regulate their ...
We describe here a new member of the LysR family of transcriptional regulators, AphB, which is requi...
Expression of genes encoding the toxin-co-regulated pilus (TCP) varies between the two biotypes of V...
Epidemic strains of Vibrio cholerae O1 are divided into two biotypes, classical and El Tor. In both ...
Epidemic strains of Vibrio cholerae O1 are divided into two biotypes, classical and El Tor. In both ...
A physical map has been constructed of the 5-kb XbaI fragment encoding the promoter proximal of regi...
Vibrio cholerae is the agent of the severe diarrheal disease cholera, and it perpetuates in aquatic ...
The two major disease-causing biotypes of Vibrio cholerae, classical and El Tor, exhibit differences...
Insertion mutations in two Vibrio cholerae genes, cya and crp, which encode adenylate cyclase and th...
AbstractThe temporal expression patterns of the critical Vibrio cholerae virulence genes, tcpA and c...
The virulence of a pathogen is dependent on a discrete set of genetic determinants and their well-re...
The aim of this work was to analyze the relationship between cellular localization and function of T...
ABSTRACT Vibrio cholerae is the etiological agent of the infectious disease cholera, which is charac...
Coordinate expression of many virulence genes in the human pathogen Vibrio cholerae is controlled by...
Co-ordinate expression of many virulence genes in the human pathogen Vibrio cholerae is under the di...
Microbes are often underestimated for the flexibility and subtlety by which they can regulate their ...