BRIEF COMMUNICATIONS Hypertension and Abnormalities of Carbohydrate Metabolism Possible Role of the Sympathetic Nervous System

To investigate the relationships between the the parameters of glucose metabolism were compared. Subjects with UNE 205 mg/day hadsympathetic nervous system (SNS) and parameters of glucose metabolism in arterial greater levels of fasting glucose and greater glycemic response to OGL than subjects withhypertension, daily urinary excretion of catecholamines and plasma glucose, insulin, and UNE 205 mg/day, whereas no significant differences between the groups were found inC-peptide response to an oral glucose load (OGL) have been evaluated in 77 untreated patients with fasting and stimulated plasma insulin and C-peptide. Thus, activation of SNS is related tomild-to-moderate essential hypertension and in 31 normotensive controls. Urinary excretion of glucose tolerance but not hyperinsulinemia and insulin hypersecretion in essential hypertension.norepinephrine (UNE) was positively correlated with body mass index and with plasma glucose Plasma glucose levels, independent of insulin, may contribute to the relationship between SNSlevels both at fast and after OGL. No correlations were found between urinary excretion of activity and blood pressure in essential hypertension. Am J Hypertens 1997;10:678–682catecholamines and plasma insulin and C-peptide levels both at fast and in response to OGL. q 1997 American Journal of Hypertension, Ltd