(PDGF) is shown to be chemotactic for monocytes and neutrophils. Maximum monocyte chemotaxis to PDGF is fully equal to that achieved with C5a and occurs at-20 ng/ml (=0.7 nM). Maximum neutrophil chemo-taxis is =60 % that achieved with C5a but occurs at 1 ng/ml (=32 pM). The chemotactic activity of PDGF is blocked by specific antisera to PDGF and by protamine sulfate, a competitive inhibitor of PDGF binding to cell surfaces. In contrast to PDGF, epider-mal growth factor shows no chemotactic activity for inflammatory cells at 0.5-100 ng/ml. The high level of chemotactic activity of PDGF suggests that in ad-dition to its role as a mitogen for smooth muscle cells and fibroblasts, PDGF may be involved in attracting inflammatory cells to sites of...
<p>Chemokines affect inflammation and cancer through leukocyte attraction and angiogenesis. He...
CC and CXC chemokines coinduced in fibroblasts and leuko-cytes by cytokines and microbial agents det...
Abstract: During recruitment, leukocytes respond to chemotaxins and traverse matrix barriers. Uroki-...
Like in the polymorphonuclear leukocyte (PMN). the plate-let-derived growth factor (PDGF) purified t...
Platelet-derived growth factor (PDGF) has been assigned a broad range of biological roles in context...
The effect of increasing doses from 1.25 to 10 ng/ml of PDGF was tested for chemotactic and mitogeni...
<p>(A) The chemotactic activity of the FTSC22 (upper panel) and FTCa1 (lower panel) cells toward a p...
tactic factors by human fibroblasts was studied. 12 lines of normal fibroblasts obtained by skin bio...
SummaryChemotaxis, migration toward soluble chemical cues, is critical for processes such as wound h...
Macrophages stimulated with lipopolysaccharide (LPS) release a factor (MNCF; macrophage-derived neut...
The present study was designed to characterize the production of chemoattractants by human melanoma ...
Bibliography: pages 71-78.Chemotaxis is a phenomenon in which cells move in the direction of a chemi...
In-vitro studies of chemotaxis of mononuclear leukocytes (MNLs) were performed to characterize humor...
<p>The expression of PDGFR family members is evaluated by RT-PCR (A) and Western Blotting (B) in GL1...
<p>(A) Growth factors enhance cells' response to LPA gradients. Figure shows plots of the WM239A pat...
<p>Chemokines affect inflammation and cancer through leukocyte attraction and angiogenesis. He...
CC and CXC chemokines coinduced in fibroblasts and leuko-cytes by cytokines and microbial agents det...
Abstract: During recruitment, leukocytes respond to chemotaxins and traverse matrix barriers. Uroki-...
Like in the polymorphonuclear leukocyte (PMN). the plate-let-derived growth factor (PDGF) purified t...
Platelet-derived growth factor (PDGF) has been assigned a broad range of biological roles in context...
The effect of increasing doses from 1.25 to 10 ng/ml of PDGF was tested for chemotactic and mitogeni...
<p>(A) The chemotactic activity of the FTSC22 (upper panel) and FTCa1 (lower panel) cells toward a p...
tactic factors by human fibroblasts was studied. 12 lines of normal fibroblasts obtained by skin bio...
SummaryChemotaxis, migration toward soluble chemical cues, is critical for processes such as wound h...
Macrophages stimulated with lipopolysaccharide (LPS) release a factor (MNCF; macrophage-derived neut...
The present study was designed to characterize the production of chemoattractants by human melanoma ...
Bibliography: pages 71-78.Chemotaxis is a phenomenon in which cells move in the direction of a chemi...
In-vitro studies of chemotaxis of mononuclear leukocytes (MNLs) were performed to characterize humor...
<p>The expression of PDGFR family members is evaluated by RT-PCR (A) and Western Blotting (B) in GL1...
<p>(A) Growth factors enhance cells' response to LPA gradients. Figure shows plots of the WM239A pat...
<p>Chemokines affect inflammation and cancer through leukocyte attraction and angiogenesis. He...
CC and CXC chemokines coinduced in fibroblasts and leuko-cytes by cytokines and microbial agents det...
Abstract: During recruitment, leukocytes respond to chemotaxins and traverse matrix barriers. Uroki-...