Cefepime: A Review of Its Use in the Treatment of Serious Bacterial Infections

Abstract: Serious bacterial infections with their high bioburden are often difficult to treat. Emergence of drug-resistant bacteria has worsened the situation, and management of these cases has become a therapeutic challenge. Prompt institution of appropriate antibiotic is vital in order to decrease complications and fatalities. Cefepime is a new fourth generation parenteral cephalosporin which holds promise for management of these severe infections. It has been shown to be useful in critical pneumonias, soft and bone tissue infec-tions, urinary tract infections and febrile neutropenia. It eradicates organisms which have shown resistance to other β-lactam antibiotics. It is stable to hydrolysis by the common plasmid and chromosomally mediated β-lactamases. The twice daily dosing and improved efficacy even at low dosage makes it a suitable alternative to ceftazidime and carbapenems. It is well tolerated by all age groups and is safe even for newborns. Cefepime monotherapy gives both a good clinical response and an excellent microbiological clearance. In order to preserve its anti-bacterial potency, prudent use of cefepime is warranted. Research into its efficacy and safety with other β-lactamase inhibitors is ongoing and will benefit mankind