Add to ORKGD ow nloaded from 2Abstract The members of the galectin family are associated with diverse cellular events including immune response. We investigated the effects of galectin-8 on neutrophil function. Human galectin-8 induced firm and reversible adhesion of peripheral blood neutrophils, but not eosinophils, to a plastic surface in a lactose-sensitive manner. Other human galectins, galectin-1,-3 and-9, showed low or negligible effects on neutrophil adhesion. Confocal microscopy revealed actin bundle formation in the presence of galectin-8. Cytochalasins inhibited both actin assembly and cell adhesion induced by galectin-8. Affinity purification of galectin-interacting proteins from solubilized neutrophil membrane revealed that N-terminal carb...
Among the responders to microbial invasion, neutrophils represent the earliest and perhaps the most ...
Galectin-9 is a member of the galectin family of proteins, which were first identified to specifical...
Galectin-3 (Gal-3), a member of a family of highly conserved carbohydrate-binding proteins, has rece...
The members of the galectin family are associated with diverse cellular events, including immune res...
We previously showed that tandem-repeat type galectin-8, which has two covalently linked carbohydrat...
Neutrophil trafficking is a key component of the inflammatory response. Here, we have investigated t...
Galectin-3 is an endogenous β-galactoside-binding lectin comprising a carbohydrate recognition domai...
The human neutrophils play important roles in the host defence against invading microorganisms. To e...
An important step of innate immune response is the re-cruitment of polymorphonuclear leukocytes (PMN...
Galectin-1 (Gal-1), the prototype of a family of β -galactoside-binding proteins, has been shown to ...
Annexin 1 (ANXA1), galectin-1 (Gal-1) and galectin-3 (Gal-3) proteins have been identified as import...
Contemporary diseases like diabetes, asthma, atherosclerosis etc. are marked by chronic inflammation...
Galectins (Gals), a family of mammalian lectins, play diverse roles under physiological and patholog...
Cellular turnover is associated with expo-sure of surface phosphatidylserine (PS) in apoptotic cells...
Galectin-8 has two different carbohydrate recognition domains (CRDs), the N-terminal Gal-8N and the ...
Among the responders to microbial invasion, neutrophils represent the earliest and perhaps the most ...
Galectin-9 is a member of the galectin family of proteins, which were first identified to specifical...
Galectin-3 (Gal-3), a member of a family of highly conserved carbohydrate-binding proteins, has rece...
The members of the galectin family are associated with diverse cellular events, including immune res...
We previously showed that tandem-repeat type galectin-8, which has two covalently linked carbohydrat...
Neutrophil trafficking is a key component of the inflammatory response. Here, we have investigated t...
Galectin-3 is an endogenous β-galactoside-binding lectin comprising a carbohydrate recognition domai...
The human neutrophils play important roles in the host defence against invading microorganisms. To e...
An important step of innate immune response is the re-cruitment of polymorphonuclear leukocytes (PMN...
Galectin-1 (Gal-1), the prototype of a family of β -galactoside-binding proteins, has been shown to ...
Annexin 1 (ANXA1), galectin-1 (Gal-1) and galectin-3 (Gal-3) proteins have been identified as import...
Contemporary diseases like diabetes, asthma, atherosclerosis etc. are marked by chronic inflammation...
Galectins (Gals), a family of mammalian lectins, play diverse roles under physiological and patholog...
Cellular turnover is associated with expo-sure of surface phosphatidylserine (PS) in apoptotic cells...
Galectin-8 has two different carbohydrate recognition domains (CRDs), the N-terminal Gal-8N and the ...
Among the responders to microbial invasion, neutrophils represent the earliest and perhaps the most ...
Galectin-9 is a member of the galectin family of proteins, which were first identified to specifical...
Galectin-3 (Gal-3), a member of a family of highly conserved carbohydrate-binding proteins, has rece...