Short-Term Hyperglycemic Dysregulation in Patients With Type 1 Diabetes Does Not Change Myocardial Triglyceride Content or Myocardial Function

OBJECTIVE — To evaluate the effects of hyperglycemia due to partial insulin deprivation on myocardial triglyceride (TG) content and myocardial function in patients with type 1 diabetes. RESEARCH DESIGNANDMETHODS — Myocardial and hepatic TG content and left ventricular (LV) function were measured by magnetic resonance (MR) spectroscopy and MR imaging during optimal glucoregulation and after 24 h of partial insulin deprivation (n 10). RESULTS — Mean insulin infusion rate was 45 5 units at baseline, whereas it was 27 5 units during hyperglycemia (per 24 h, P 0.001). Plasma glucose levels increased from 8.4 0.6 to 15.9 0.8 mmol/l (P 0.001), and plasma levels of nonesterified fatty acids from 0.31 0.05 to 0.46 0.07 mmol/l (P 0.015). Hyperglycemia had no effects on myocardial or hepatic TG content and LV function. CONCLUSIONS — Short-term hyperglycemic dysregulation does not modulate myocardial or hepatic TG content or myocardial function, despite considerable metabolic adaptations. Diabetes Care 31:1613–1614, 2008 Intramyocellular triglyceride (TG) con-tent in skeletal muscle is increased inpatients with type 1 diabetes compared with that in control subjects (1), suggest