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ii Glaucoma is a critical eye condition that would eventually cause vision loss and irreversible blindness due to the damage of optic nerves. High intraocular pressure (IOP) is frequently associated with this disease and hence often used as a diagnostic parameter for screening and management of glaucoma. Topical anti-glaucoma drug, Prostaglandin, has been shown to be effective in lowering IOP with few side effects. However, it was also found that Prostaglandin could alter the structural properties of ocular tissue such as the cornea. Goldmann Applanation Tonometry (GAT), which has been the clinical standard in measuring intraocular pressure in glaucoma patients, is used with assumptions that the structural and biomechanical properties of cornea are negligible. The change in corneal properties due to drug effect may thus directly interfere the IOP measurements, resulting in artificially low IOP readings. Therefore, the purpose of this study is to investigate the potential influence of prostaglandin drugs on cornea stiffness and the IOP measurement. This is accomplished by treating canine eyes with Prostaglandin analog