Background: The contaminant isolated from contaminated heparin was oversulfated chondroitin sulfate (OSCS). Other possible contaminants should be evaluated. Methods: Contaminants were isolated from recalled contaminated heparin and were com-pared to OSCS from animal sources and to heparin by-products synthetically persulfated. Results: A great variability in molecular weight was observed in the isolated contaminants. Dermatan sulfate with high-molecular-weight in addition to OSCS was detected. Oversulfated chondroitin sulfate from different sources as well as heparin by-products produced activation of prekal-likrein to kallikrein at variable rates as measured by the generation of kallikrein. All agents produced activation of the complement ...
Oversulfated chondroitin sulfate (OSCS) has become the subject of multidisciplinary investigation as...
Heparan sulfate (HS) and heparin (HP) are functionally important glycosaminoglycans, which interact ...
Cytotoxic and pro-inflammatory histones are present in neutrophil extracellular traps (NETs) and are...
Abstract: Heparin, a widely used anticoagulant, is being rapidly displaced by low-molecular-weight h...
Oversulfated chrondroitin sulfate (OSCS) was recently identified as a contaminant of heparin and was...
ABSTRACT: Heparin is a critically important anticoagulant drug that was contaminated with a persulfo...
Heparin is a widely used anticoagulant and antithrombotic agent. Recently, a contaminant, oversulfat...
Oversulfated chondroitin sulfate (OSCS) was identified as a contaminant in certain heparin preparati...
Nowadays, pharmaceutical heparin is purified from porcine and bovine intestinal mucosa. In the past ...
Heparin is a vital pharmaceutical anticoagulant drug and remains one of the few naturally sourced ph...
Heparin is a critically important anticoagulant drug that was contaminated with a persulfonated poly...
associated with anaphylactoid-type reactions. Oversulfated chondroitin sulfate (OSCS), a semi-synthe...
Oversulfated chondroitin sulfate (OSCS) was identified as a contaminant in certain heparin preparati...
Heparin, the focus of this review, is a critically important anticoagulant drug produced from animal...
Heparin is a vital pharmaceutical anticoagulant drug and remains one of the few naturally sourced ph...
Oversulfated chondroitin sulfate (OSCS) has become the subject of multidisciplinary investigation as...
Heparan sulfate (HS) and heparin (HP) are functionally important glycosaminoglycans, which interact ...
Cytotoxic and pro-inflammatory histones are present in neutrophil extracellular traps (NETs) and are...
Abstract: Heparin, a widely used anticoagulant, is being rapidly displaced by low-molecular-weight h...
Oversulfated chrondroitin sulfate (OSCS) was recently identified as a contaminant of heparin and was...
ABSTRACT: Heparin is a critically important anticoagulant drug that was contaminated with a persulfo...
Heparin is a widely used anticoagulant and antithrombotic agent. Recently, a contaminant, oversulfat...
Oversulfated chondroitin sulfate (OSCS) was identified as a contaminant in certain heparin preparati...
Nowadays, pharmaceutical heparin is purified from porcine and bovine intestinal mucosa. In the past ...
Heparin is a vital pharmaceutical anticoagulant drug and remains one of the few naturally sourced ph...
Heparin is a critically important anticoagulant drug that was contaminated with a persulfonated poly...
associated with anaphylactoid-type reactions. Oversulfated chondroitin sulfate (OSCS), a semi-synthe...
Oversulfated chondroitin sulfate (OSCS) was identified as a contaminant in certain heparin preparati...
Heparin, the focus of this review, is a critically important anticoagulant drug produced from animal...
Heparin is a vital pharmaceutical anticoagulant drug and remains one of the few naturally sourced ph...
Oversulfated chondroitin sulfate (OSCS) has become the subject of multidisciplinary investigation as...
Heparan sulfate (HS) and heparin (HP) are functionally important glycosaminoglycans, which interact ...
Cytotoxic and pro-inflammatory histones are present in neutrophil extracellular traps (NETs) and are...