The effect of estrogen replacement therapy on plasma nitric oxide and endothelin-1 levels in postmenopausal women

postmenopausal women decreases cardiac mortality and improves endothelial function. The endothelium regulates vascular tone and growth by releasing such factors as nitric oxide and endothelin-1. Objective: To determine whether ERT alters the balance between the total oxidized products of nitric oxide and endothelin-1. Design: Single-arm, before-after clinical tr ial. Setting: Outpatient clinical research center of an aca-demic medical center