to Parvovirus B19 with Distribution on the Distal Extremities and the Face

We describe 3 patients who presented with a distinctive clini-cal picture of the purpuric rash called “gloves-and-socks syn-drome ” which was characterized by an acral distribution of the rash that involved not only the distal part of the extrem-ities but also the chin and perioral area. Serologic analysis for parvovirus B19 yielded positive results. Parvovirus B19 should be included in the evaluation of febrile purpura. Human parvovirus B19 infection is a recognized cause of sev-eral clinical syndromes, such as aplastic crisis in chronic he-molytic anemia, hydrops fetalis, and arthropathy. It also has been associated with dermatologic manifestations, namely, the classic rash of erythema infectiosum, vesiculopustular rash, purpura in the absence of thrombocytopenia, Schönlein-Hen-och purpura, and “gloves-and-socks syndrome ” (PPGSS) [1]. Here we describe 3 patients with a new clinical presentation o