Hydrogen sulfide prevents ethanol-induced gastric damage in mice: Role of ATP-sensitive potassium channels and capsaicin-sensitive primary afferent neurons

The aim of this study was to evaluate the protective effect of hydrogen sulfide (H2S) on ethanol-induced gastric lesions in mice and the influence of ATP-sensitive potassium (KATP) chan-nels, capsaicin-sensitive sensory afferent neurons, and tran-sient receptor potential vanilloid (TRPV) 1 receptors on such an effect. Saline and L-cysteine alone or with propargylglycine, sodium hydrogen sulfide (NaHS), or Lawesson’s reagent were administrated for testing purposes. For other experiments, mice were pretreated with glibenclamide, neurotoxic doses of capsaicin, or capsazepine. Afterward, mice received L-cysteine, NaHS, or Lawesson’s reagent. After 30 min, 50 % ethanol was administrated by gavage. After 1 h, mice were sacrificed, and gastric damage was evaluated by macroscopic and micro-scopic analyses. L-Cysteine, NaHS, and Lawesson’s reagen