Role of microsomal prostaglandin E synthase-1 in the facilitation of angiogenesis and the healing of gastric ulcers

microsomal prostaglandin E synthase-1 in the facilitation of angio-genesis and the healing of gastric ulcers. Am J Physiol Gastrointest Liver Physiol 299: G1139–G1146, 2010. First published September 2, 2010; doi:10.1152/ajpgi.00013.2010.—The importance of prostaglan-din E2 in various pathophysiological events emphasizes the necessity of understanding the role of PGE synthases (PGESs) in vivo. How-ever, there has been no report on the functional relevance of micro-somal PGES-1 (mPGES-1) to the physiological healing processes of gastric ulcers, or to angiogenesis, which is indispensable to the healing processes. In this report, we tested whether mPGES-1 plays a role in the healing of gastric ulcers and in the enhancement of angiogenesis using mPGES-1 knockout mice (mPGES-1 KO mice) and their wild-type (WT) counterparts. Gastric ulcers were induced by the serosal application of 100 % acetic acid, and the areas of the ulcers were measured thereafter. mPGES-1 together with cyclooxygenase-