Therapeutic Discovery Dihydroartemisinin Induces Apoptosis Intrinsic Pathway

The sesquiterpene lactone dihydroartemisinin (DHA), a drug artemisinin, is cytotoxic to human tumor cells. Tre duced a breakdown of the mitochondrial transmembran caspases, and DNA fragmentation indicative of apopto caspase-8 did not alter apoptosis rates in Jurkat cells, ov ytoto tein B A-ind f Bak in ce the f caven uced ption bran