2 Like most phages with double-stranded DNA, phage T4 exits the infected host cell by a lytic process requiring, at a minimum, an endolysin and a holin. Unlike most phages, T4 can sense superinfection (which signals the depletion of uninfected host cells) and responds by delaying lysis and achieving an order-of-magnitude increase in burst size using a mechanism called lysis inhibition (LIN). T4 r mutants that are unable to conduct LIN produce distinctly large, sharp-edged plaques. The discovery of r mutants was key to the foundations of molecular biology, in particular to discovering and characterizing genetic recombination in T4, to redefining the nature of the gene, and to exploring the mutation process at the nucleotide level of resoluti...
Virulent mutations in the bacteriophage Mu repressor gene were isolated and characterized. Recombina...
Abstract Background Viruses are obligate intracellular parasites that rely upon the host cell for di...
Due to the character of the original source materials and the nature of batch digitization, quality ...
Like most phages with double-stranded DNA, phage T4 exits the infected host cell by a lytic process ...
Under normal conditions, phage T4-infected bacteria lyse at a characteristic time after infection, e...
A system of amber mutants has been developed for each of the T-even phages T2, T6, and RB69. In T2 t...
T4 requires two proteins: holin, T (lesion formation and lysis timing) and endolysin, E (cell wall d...
Recombinational repair is a widespread mechanism for dealing with DNA damage. It is found in both pr...
Genetic exclusion in phage T4 is the prime responsibility of the imm and sp genes. The map region co...
Phage Mu's c gene product is a cooperative regulatory protein that binds to a large, complex, t...
The lytic bacteriophage T4 uses multiple mechanisms to initiate the replication of its DNA. Initiati...
The hok (host killing) and sok (suppressor of killing) genes (hok/sok) efficiently maintain the low-...
Transfer functions of the conjugative plasmid RP4 (IncPot) are distributed among distinct regions of...
Like all phages, T4 requires a holin (T) to effect lysis. The lysis event depends on the temporally...
Bacteriophage T4 lysozyme (T4L) is a glycosidase that is widely applied as a natural antimicrobial a...
Virulent mutations in the bacteriophage Mu repressor gene were isolated and characterized. Recombina...
Abstract Background Viruses are obligate intracellular parasites that rely upon the host cell for di...
Due to the character of the original source materials and the nature of batch digitization, quality ...
Like most phages with double-stranded DNA, phage T4 exits the infected host cell by a lytic process ...
Under normal conditions, phage T4-infected bacteria lyse at a characteristic time after infection, e...
A system of amber mutants has been developed for each of the T-even phages T2, T6, and RB69. In T2 t...
T4 requires two proteins: holin, T (lesion formation and lysis timing) and endolysin, E (cell wall d...
Recombinational repair is a widespread mechanism for dealing with DNA damage. It is found in both pr...
Genetic exclusion in phage T4 is the prime responsibility of the imm and sp genes. The map region co...
Phage Mu's c gene product is a cooperative regulatory protein that binds to a large, complex, t...
The lytic bacteriophage T4 uses multiple mechanisms to initiate the replication of its DNA. Initiati...
The hok (host killing) and sok (suppressor of killing) genes (hok/sok) efficiently maintain the low-...
Transfer functions of the conjugative plasmid RP4 (IncPot) are distributed among distinct regions of...
Like all phages, T4 requires a holin (T) to effect lysis. The lysis event depends on the temporally...
Bacteriophage T4 lysozyme (T4L) is a glycosidase that is widely applied as a natural antimicrobial a...
Virulent mutations in the bacteriophage Mu repressor gene were isolated and characterized. Recombina...
Abstract Background Viruses are obligate intracellular parasites that rely upon the host cell for di...
Due to the character of the original source materials and the nature of batch digitization, quality ...