Granulomatous disease in common variable immunodeficiency

found in the lymphoid or solid organs of patients with common variable immunodeficiency. Objective: To examine the clinical and immunologic con-ditions in patients with common variable immunodefi-ciency who have granulomas. Design: Case series. Setting: Large tertiary care medical center. Patients: 17 hypogammaglobulinemic patients with common variable immunodeficiency whose organ ortissue biopsy samples contained noncaseating granulomas. Measurements: Results of lymphocyte function tests. Results: Eight of 17 patients had granulomas at some point before hypogammaglobulinemia was diagnosed. Sixteen of the 17 had deficient T-cell proliferation to mi-togens. Although 14 patients received standard treatmen