Penicilloyl-polylysine intradermal testing for penicillin hypersensitivity

The immunochemical mechanisms involved in peni-cillin allergy have been the subject of numerous investigations during the past 10 years. Considerable progress in understanding how patients become sensitized to penicillin has been made since the publi-cations by Levine (1960) and Weck and Eisen (1960) on various antigenic determinants involved in con-tact hypersensitivity to penicillin as well as the immunological properties of penicillanic acid, an antigenic derivative of penicillin. Also noteworthy have been the independent investigations of Levin