Original Contributions A Model of the Ventricular Cardiac Action Potential Depolarization, Repolarization

A mathematical model of the membrane action potential of the mammalian ventricular cell is introduced. The model is based, whenever possible, on recent single-cell and single-channel data and incorporates the possibility of changing extracellular potassium concentration [K].. The fast sodium current, 'Nap is characterized by fast upstroke velocity (Vma.=400 V/sec) and slow recovery from inactivation. The time-independent potassium current, IKI, includes a negative-slope phase and displays significant crossover phenomenon as [K], is varied. The time-dependent potassium current, IK, shows only a minimal degree of crossover. A novel potassium current that activates at plateau potentials is included in the model. The simulated action potential duplicates the experimentally observed effects of changes in [K], on action potential duration and rest potential. Physiological simulations focus on the interaction between depolarization and repolarization (i.e., premature stimulation). Results demonstrate the importance of the slow recovery of INa in determining the response of the cell. Simulated responses to periodic stimulation include monotonic Wenckebach patterns and alternans at normal [K]0, whereas at low [K]0 nonmono-tonic Wenckebach periodicities, aperiodic patterns, and enhanced supernormal excitability that results in unstable responses ("chaotic activity") are observed. The results are consistent wit