1 Bioinformatics Challenges for Personalized Medicine

Motivation: Widespread availability of low-cost, full genome se-quencing will introduce new challenges for bioinformatics. Results: This review outlines recent developments in sequencing technologies and genome analysis methods for application in per-sonalized medicine. New methods are needed in four areas to real-ize the potential of personalized medicine: 1) processing large-scale robust genomic data; 2) interpreting the functional effect and the impact of genomic variation; 3) integrating systems data to relate complex genetic interactions with phenotypes; and 4) translating these discoveries into medical practice. Contact