Printed in Great Britain THE EFFECT OF 2-PHENYL ETHANOL ON THE DNA SYNTHESIS CYCLE OF

The effect of different concentrations of 2-phenyl ethanol (PE) on growth and DNA synthesis of Schizosaccharomyces pombe is described. 0-3 % PE inhibits the entry of cells into 5 phase, but allows a doubling in the number of cells in the culture. The effect of 0-2 % PE on random and synchronous cultures of S. pombe shows that, in the continued presence of the inhibitor, the S phase is moved to a different point in the cell cycle. Cells continue to grow in the presence of o-2 % PE with a G, phase occupying a significant portion of the cell cycle. This differs from normal growth when the Gt phase is absent