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Background: The World health Organization (WhO) and United Nations Children's Fund (UNICEF) initiated intensive efforts to trans-form hospitals into breastfeeding support centers through the Baby Friendly hospital Initiative (BFhI). The study populations in this study were geographically located within the vicinity of a BFhI designated hospital in Lagos, Nigeria. The aim of this study was to determine the knowledge, attitude and practice of exclusive breast feeding among mothers in two semi-urban areas around a BFhI designated hospital. Method: Four hundred self-administered questionnaires were distri-buted to mothers from two semi urban areas in Surulere Local Go-vernment Area of Lagos, Nigeria to ascertain their socio demographic data, knowledge, attitude and practice of exclusive breastfeeding. Approval for the study was granted by the Ethics Committee. The respondents were chosen by simple random sampling. The questions covered socio demographic data, knowledge, attitude and the practi-ce of exclusive breastfeeding (EBF). Collected data was analyzed and investigated for statistical associations. Results: The knowledge, attitude and practice of exclusive breast-feeding amongst mothers in the semi urban area of Lagos, Nigeria is statistically significantly affected by their educational level and by their professional level. Those with a higher level of education were more likely to have a correct knowledge (P < 0.05). Religion, educa