Regulation of SV40 Tumor Antigen in Transformed Mouse 3T3 Cells

intranuclear antigen present during both productive and abortive infections, as well as in all species of animal cells transformed by SV40. Evidence pre-sented by Brandner and Mueller (this volume) strongly suggests that T antigen is a primary viral gene product rather than an induced cellular anti-gen. The regulation of the integrated SV40 genome in transformed cells can therefore be investigated by studying the regulation of T antigen in trans-formed cells. Correlations can lso be made between the regulation of T antigen and the regulation of the transformed phenotype. Renger and Bascilico (1973) have identified a cellular function that regu-lates the transformed phenotype of SV40-trans-formed 3T3 cells. The cellular mutation is tempera