Add to ORKGPURPOSE: To investigate if oxymatrine pretreatment could ameliorate renal I/R injury induced in rats and explore the possible role of oxymatrine in Nrf2/HO-1 pathway. METHODS: Unilaterally nephrectomized rats were insulted by I/R in their left kidney. Twenty four rats were randomly divided into three groups: sham group, I/R + saline-treated group, I/R + OMT-treated group. Oxymatrine or vehicle solution was administered intraperitoneally injected 60 min before renal ischemia, respectively. Renal function, histology, makers of oxidative stress, cell apoptosis and Nrf2/HO-1 expressions were assessed. RESULTS: Oxymatrine pretreatment exhibited an improved renal functional recovery, alleviated histological injury and oxidative stress, inhibiting...
Massive intravascular hemolysis is associated with acute kidney injury (AKI). Nuclear factor erythro...
Background. Oxymatrine (OMT) is the primary pharmacological component of Sophora flavescens Aiton., ...
Exacerbated oxidative stress and inflammation may induce three types of programmed cell death, autop...
PURPOSE:To investigate if oxymatrine pretreatment could ameliorate renal I/R injury induced in rats ...
Background/Aims: Renal ischemia-reperfusion injury (IRI) is a common consequence of acute kidney inj...
Background: Renal ischemia-reperfusion (I/R) injury is a major cause of acute kidney injury. The pat...
Background/Aims: Chronic renal allograft dysfunction (CRAD) is a leading cause of long-term renal al...
Most chronic kidney disease inevitably progress to renal fibrosis. Tubular epithelial- to-mesenchyma...
Background: Renal ischemiaereperfusion (I/R) injury is a major cause of acute kidney failure by mech...
Aim: The objective of the present study was to evaluate the protective effects of halofuginone again...
Objective: To explore the theraputic effects and potential mechanisms of hydrogen-rich water (HRW) a...
BackgroundTubulo-interstitial nephropathy (TIN) is a common cause of chronic kidney disease (CKD). C...
Abstract Nephropathy can occur following exposure of the kidneys to oxidative stress. Oxidative stre...
Exacerbated oxidative stress and inflammation may induce three types of programmed cell death, autop...
Objectives: Ischemia‑reperfusion (IR) contributes to the development acute renal failure.Oxygen free...
Massive intravascular hemolysis is associated with acute kidney injury (AKI). Nuclear factor erythro...
Background. Oxymatrine (OMT) is the primary pharmacological component of Sophora flavescens Aiton., ...
Exacerbated oxidative stress and inflammation may induce three types of programmed cell death, autop...
PURPOSE:To investigate if oxymatrine pretreatment could ameliorate renal I/R injury induced in rats ...
Background/Aims: Renal ischemia-reperfusion injury (IRI) is a common consequence of acute kidney inj...
Background: Renal ischemia-reperfusion (I/R) injury is a major cause of acute kidney injury. The pat...
Background/Aims: Chronic renal allograft dysfunction (CRAD) is a leading cause of long-term renal al...
Most chronic kidney disease inevitably progress to renal fibrosis. Tubular epithelial- to-mesenchyma...
Background: Renal ischemiaereperfusion (I/R) injury is a major cause of acute kidney failure by mech...
Aim: The objective of the present study was to evaluate the protective effects of halofuginone again...
Objective: To explore the theraputic effects and potential mechanisms of hydrogen-rich water (HRW) a...
BackgroundTubulo-interstitial nephropathy (TIN) is a common cause of chronic kidney disease (CKD). C...
Abstract Nephropathy can occur following exposure of the kidneys to oxidative stress. Oxidative stre...
Exacerbated oxidative stress and inflammation may induce three types of programmed cell death, autop...
Objectives: Ischemia‑reperfusion (IR) contributes to the development acute renal failure.Oxygen free...
Massive intravascular hemolysis is associated with acute kidney injury (AKI). Nuclear factor erythro...
Background. Oxymatrine (OMT) is the primary pharmacological component of Sophora flavescens Aiton., ...
Exacerbated oxidative stress and inflammation may induce three types of programmed cell death, autop...