Add to ORKGBasic considerations involved in the interaction of drugs with proteins are reviewed. The important role of the concentration of unbound drug in determining therapeutic and toxicologic effects is emphasized. Ultra filtration is suggested to be the method of choice for the determination of concentrations of unbound drug in plasma in clinical practice
2. Reidenberg MM. The binding of drugs to plasma proteins and the interpretation of measurements of ...
A displacement equation describing competitive binding of drugs to protein in solution is derived an...
The binding of drugs with proteins in blood, serum or plasma is an important process in determining ...
The extent of drug binding to plasma proteins, determined by measuring the free active fraction, has...
"""Binding to plasma proteins highly influences drug efficacy, distribution, and disposition. Serum ...
"""Binding to plasma proteins highly influences drug efficacy, distribution, and disposition. Serum ...
Drug molecules in vivo may be bound to proteins and lipids in plasma and/or in tissues, or free (unb...
The liver is a major site for synthesis and catabolism of plasma proteins. Albumin has various bindi...
The liver is a major site for synthesis and catabolism of plasma proteins. Albumin has various bindi...
Drug-protein interactions in plasma play an important role in the distribution, excretion and metabo...
Drug-protein interactions in plasma play an important role in the distribution, excretion and metabo...
Drug-protein interactions in plasma play an important role in the distribution, excretion and metabo...
A diafiltration technique was used to study drug-protein interactions. Fraction V human serum albumi...
A diafiltration technique was used to study drug-protein interactions. Fraction V human serum albumi...
For very highly bound drugs (fu<2%) the determination of the unbound fraction in plasma (fu) and a r...
2. Reidenberg MM. The binding of drugs to plasma proteins and the interpretation of measurements of ...
A displacement equation describing competitive binding of drugs to protein in solution is derived an...
The binding of drugs with proteins in blood, serum or plasma is an important process in determining ...
The extent of drug binding to plasma proteins, determined by measuring the free active fraction, has...
"""Binding to plasma proteins highly influences drug efficacy, distribution, and disposition. Serum ...
"""Binding to plasma proteins highly influences drug efficacy, distribution, and disposition. Serum ...
Drug molecules in vivo may be bound to proteins and lipids in plasma and/or in tissues, or free (unb...
The liver is a major site for synthesis and catabolism of plasma proteins. Albumin has various bindi...
The liver is a major site for synthesis and catabolism of plasma proteins. Albumin has various bindi...
Drug-protein interactions in plasma play an important role in the distribution, excretion and metabo...
Drug-protein interactions in plasma play an important role in the distribution, excretion and metabo...
Drug-protein interactions in plasma play an important role in the distribution, excretion and metabo...
A diafiltration technique was used to study drug-protein interactions. Fraction V human serum albumi...
A diafiltration technique was used to study drug-protein interactions. Fraction V human serum albumi...
For very highly bound drugs (fu<2%) the determination of the unbound fraction in plasma (fu) and a r...
2. Reidenberg MM. The binding of drugs to plasma proteins and the interpretation of measurements of ...
A displacement equation describing competitive binding of drugs to protein in solution is derived an...
The binding of drugs with proteins in blood, serum or plasma is an important process in determining ...