Although histone deacetylase (HDAC) inhibitors are appreciated as a promising class of anticancer drugs, recent reports show that P-glycoprotein (P-gp) is induced by HDAC inhibitor treatment in cancer cells, resulting in multidrug resistance of cancer cells to other chemotherapeutic agents. In this study, we investigated the molecular mechanism of HDAC inhibitor induction of P-gp expression. HDAC inhibitor treatment causes cell type–specific induction of P-gp expression without changes in the CpG methylation status of the promoter region. In addition, our data show that HDAC inhibitor does not alter the DNA binding activity of Sp1 but facilitates both the recruitment of a coactivator complex that includes CAAT/enhancer binding protein β and...
Chromatin is a dynamic macromolecular structure epigenetically modified to regulate specific gene ex...
© 2011 Dr. Andrea NewboldThe opposing activities of histone acetyltransferases (HATs) and histone de...
Inappropriate control of expression of genetic information is the cause of many forms ofcancer. Aber...
Background. Despite recent success toward discovery of more effective anticancer drugs, chemoresista...
Histone deacetylase inhibitors (HDACIs) represent a new class of targeted anticancer agents. Here, ...
Histone deacetylase inhibitors (HDACIs) represent a new class of targeted anticancer agents. Here, ...
Histone Deacetylase Inhibitors (HDACi) are a new class of chemotherapeutics which have shown promise...
Histone deacetylase inhibitor (HDACi) has been shown to demethylate the mammalian genome, which furt...
Histone deacetylase inhibitors (HDIs) are a group of chemo-preventive and chemo-therapeutic agents t...
Histone deacetylase inhibitor (HDACi) has been shown to demethylate the mammalian genome, which furt...
BACKGROUND: Small molecule inhibitors of histone deacetylases (HDACi) hold promise as anticancer age...
This study investigates the mechanism by which histone deacetylase HDAC inhibitors up-regulate histo...
ABCG2 is a ubiquitous ATP-binding cassette transmembrane protein that is important in pharmacology a...
Histone deacetylase inhibitors induce cell cycle arrest and apoptosis in tumor cells and are therefo...
peer reviewedHistone deacetylase inhibitors induce cell cycle arrest and apoptosis in tumor cells an...
Chromatin is a dynamic macromolecular structure epigenetically modified to regulate specific gene ex...
© 2011 Dr. Andrea NewboldThe opposing activities of histone acetyltransferases (HATs) and histone de...
Inappropriate control of expression of genetic information is the cause of many forms ofcancer. Aber...
Background. Despite recent success toward discovery of more effective anticancer drugs, chemoresista...
Histone deacetylase inhibitors (HDACIs) represent a new class of targeted anticancer agents. Here, ...
Histone deacetylase inhibitors (HDACIs) represent a new class of targeted anticancer agents. Here, ...
Histone Deacetylase Inhibitors (HDACi) are a new class of chemotherapeutics which have shown promise...
Histone deacetylase inhibitor (HDACi) has been shown to demethylate the mammalian genome, which furt...
Histone deacetylase inhibitors (HDIs) are a group of chemo-preventive and chemo-therapeutic agents t...
Histone deacetylase inhibitor (HDACi) has been shown to demethylate the mammalian genome, which furt...
BACKGROUND: Small molecule inhibitors of histone deacetylases (HDACi) hold promise as anticancer age...
This study investigates the mechanism by which histone deacetylase HDAC inhibitors up-regulate histo...
ABCG2 is a ubiquitous ATP-binding cassette transmembrane protein that is important in pharmacology a...
Histone deacetylase inhibitors induce cell cycle arrest and apoptosis in tumor cells and are therefo...
peer reviewedHistone deacetylase inhibitors induce cell cycle arrest and apoptosis in tumor cells an...
Chromatin is a dynamic macromolecular structure epigenetically modified to regulate specific gene ex...
© 2011 Dr. Andrea NewboldThe opposing activities of histone acetyltransferases (HATs) and histone de...
Inappropriate control of expression of genetic information is the cause of many forms ofcancer. Aber...