in Mice: Concise Communication

The pharmacodynamics of technetium-99m stannous citrate were studied in Yale—Swiss mice bearing a sarcoma-like transplantable brain tumor, and the renal kinetics were determined in normal mice. Using a rating system based on tumor uptake and tumor-to-brain, tumor-to-blood, and tumor-to skin ratios, the data obtained with this compound were compared with similar data obtained previously in the same model with Tc-99m Fe-(ascorbic acid), Tc-99m Fe-(ascorbic acid)-DTPA, Tc-99m Sn.DTPA, [99―Tc] per technetate, and [ssmTc] pertechnetate with perchiorate predose. Technetium 99m stannous citrate does not appear to achieve tumor localization by a mode different from these other Tc-99m-labeled compounds, nor does it show any potential advantage as a scanning agent in this tumor model. J Nuci Med 18: 915—918,1977 Recently a new tumor-seeking agent, the tech netium-99m citrate complex, has been described which, according to the information available, “has a rapid and high tumor uptake, making it especiall