Analysis of Methylation Patterns of Some Tumor Suppressor Genes in Non-Small Cell Lung Cancer Using the Multiplex Ligation-Dependent Probe Amplification [MLPA] Method

Lung cancer has the leading mortality rate among all cancer types and is the second most common cause of death after cardiovascular diseases. Apart from being an epigenetic mechanism, methylation is also a molecular mechanism which inhibits cancer-related gene expression although there is no mutation at DNA level. The aim of this study was to analyze a probe panel interrogated DNA for methylation patterns in 24 tumor suppressor genes in non-small cell lung cancer using the Methylation Specific- Multiplex Ligation-dependent Probe Amplification [MS-MLPA] method the Multiplex Liga-tion-dependent Probe Amplification [MLPA] method. Previously examined clinically and histopathologically diagnosed