Add to ORKGD ow nloaded from 2 Background: In T3 rectal cancer (RC), preoperative chemoradiotherapy (5-FU-RT) reduces local recurrences, but does not impact overall survival. New therapeutic options are still necessary to improve clinical outcomes. Patients and Methods: This randomized, non-comparative, open-label, multicenter, two arms, phase II study was conducted in MRI-defined locally advanced T3 resectable RC. In Arm A, patients received 12-week bevacizumab plus 5-FU, Leucovorin and oxaliplatin (Folfox-4) followed with bevacizumab-5-FU-RT before total mesorectal excision (TME). In Arm B, patients received only bevacizumab-5-FU-RT before TME. Primary endpoint was pathological complete response (pCR) rate. Results: Forty-six patients were randomize...
BACKGROUND: Transanal local excision has been suggested as an attractive approach for patients with ...
Background: Induction chemotherapy has been suggested to impact on preoperative chemoradiation effic...
Background: Neoadjuvant chemotherapy (NAC) allows earlier treatment of rectal cancer micro-metastase...
BACKGROUND: In locally advanced rectal cancer (LARC) preoperative chemoradiation (CRT) is the standa...
Purpose: To prospectively compare the rates of pathologic response, acute toxicity, and sphincter pr...
Background: perioperatory chemoradiotherapy (CRT) improves local control and survival in patients wi...
Background : Preoperative radiotherapy (RT) decreases local recurrence rate and improves survival in...
BACKGROUND: Systemic relapses remain a major problem in locally advanced rectal cancer. Using short-...
The discussion on the role of adjuvant chemotherapy for rectal cancer patients treated according to ...
Mucinous carcinoma (MC) is a distinct form of rectal cancer (RC) comprising 10?% of all cases and ha...
Colorectal cancer is the 3rd most common malignant disease worldwide and it represents the major pub...
WOS: 000343887400016PubMed ID: 24218281The study populations of previous preoperative chemoradiother...
In Western countries, the standard treatment for locally advanced rectal cancer is preopera-tive che...
BACKGROUND: Rectal cancer surgery is accompanied with high morbidity and poor long term functional o...
BACKGROUND: Transanal local excision has been suggested as an attractive approach for patients with ...
Background: Induction chemotherapy has been suggested to impact on preoperative chemoradiation effic...
Background: Neoadjuvant chemotherapy (NAC) allows earlier treatment of rectal cancer micro-metastase...
BACKGROUND: In locally advanced rectal cancer (LARC) preoperative chemoradiation (CRT) is the standa...
Purpose: To prospectively compare the rates of pathologic response, acute toxicity, and sphincter pr...
Background: perioperatory chemoradiotherapy (CRT) improves local control and survival in patients wi...
Background : Preoperative radiotherapy (RT) decreases local recurrence rate and improves survival in...
BACKGROUND: Systemic relapses remain a major problem in locally advanced rectal cancer. Using short-...
The discussion on the role of adjuvant chemotherapy for rectal cancer patients treated according to ...
Mucinous carcinoma (MC) is a distinct form of rectal cancer (RC) comprising 10?% of all cases and ha...
Colorectal cancer is the 3rd most common malignant disease worldwide and it represents the major pub...
WOS: 000343887400016PubMed ID: 24218281The study populations of previous preoperative chemoradiother...
In Western countries, the standard treatment for locally advanced rectal cancer is preopera-tive che...
BACKGROUND: Rectal cancer surgery is accompanied with high morbidity and poor long term functional o...
BACKGROUND: Transanal local excision has been suggested as an attractive approach for patients with ...
Background: Induction chemotherapy has been suggested to impact on preoperative chemoradiation effic...
Background: Neoadjuvant chemotherapy (NAC) allows earlier treatment of rectal cancer micro-metastase...