5Blood Centers of the Pacific CORRESPONDING AUTHOR:

Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-related mortality. To determine TRALI incidence by prospective, active surveillance and to identify risk factors by a case-control study, two academic medical centers enrolled 89 cases and 164 transfused controls. Recipient risk factors identified by multivariate analysis were higher interleukin-8 levels, liver surgery, chronic alcohol abuse, shock, higher peak airway pressure while being mechanically ventilated, current smoking and positive fluid balance. Transfusion risk factors were receipt of plasma or whole blood from female donors (OR 4.5, 95 % CI 1.85 t