Efficacy, Tolerability, and Safety of Calcipotriol Ointment in Disorders of Keratinization Results of a Randomized, Double-blind, Vehicle-Controlled, Right/Left Comparative Study

tion are a heterogeneous group of diseases that have in common a defect in cornification. The bioactive form of vitamin D3 has been shown to modulate epidermal pro liferation and differentiation. The purpose of the pres ent study was to determine the effect of the synthetic vi tamin D3 calcipotriol in a randomized, double-blind, placebo-controlled, right/left comparative study. The 67 patients included in the study were at least 12 years of age and had the following diseases: ichthyosis vulgaris (n=9), X-linked ichthyosis (n=8), congenital ichthyosis (n=10), hereditary palmoplantar keratoderma (n=20), keratosis pilaris (n=9), and Darier’s disease (n = ll). Cal cipotriol ointment (50 fxg/g) and placebo (vehicle of cal cipotriol ointment) were applied to all patients twice daily for up to 12 weeks. The patients were allowed to use u