A/T mutations at immunoglobulin loci are introduced by DNA polymerase (Pol) during an Msh2/6-dependent repair process which results in A’s being mutated 2-fold more often than T’s. This patch synthesis is initiated by a DNA incision event whose origin is still obscure. We report here the analysis of A/T oligonucleotide mutation substrates inserted at the heavy chain locus, including or not including internal C’s or G’s. Surprisingly, the template composed of only A’s and T’s was highly mutated over its entire 90-bp length, with a 2-fold decrease in mutation from the 5 = to the 3 = end and a constant A/T ratio of 4. These results imply that Pol synthesis was initiated from a break in the 5=-flanking region of the substrate and proceeded ov...
Somatic hypermutation (SHM) of immunoglobulin (Ig) genes plays a key role in antibody mediated immun...
Somatic hypermutation of immunoglobulin genes is an important contributor to antibody diversity. Lac...
To determine whether DNA polymerase plays a role in the hypermutation of immunoglobulin variable gen...
B cells produce a diverse array of antibody specificities that are of low affinity during the initia...
During somatic hypermutation (SHM) of antibody variable (V) region genes, activation-induced cytidin...
AbstractIg somatic mutations would be introduced by a polymerase (pol) while repairing DNA outside m...
International audienceMutations at A/T bases within immunoglobulin genes have been shown to be gener...
The DNA sequence data of the somatic hypermutation (SHM) field published since 1984 has been critica...
International audienceSomatic hypermutation (SHM) of immunoglobulin (Ig) genes is a B cell specific ...
Somatic hypermutation of Ig genes is initiated by transcription-coupled cytidine deamination in Ig l...
A¤nity maturation of the humoral immune response is based on the ability of immunoglobulin variable ...
AbstractAs the rate of Ig gene hypermutation approximates the level of nucleotide discrimination of ...
AbstractSomatic hypermutation (SHM) of immunoglobulin (Ig) genes appears to involve the generation o...
<p>DNA polymerase (pol) η is a specialized error-prone polymerase with at least two quite different ...
The history and current development of the reverse transcriptase model of somatic hypermutation (RT-...
Somatic hypermutation (SHM) of immunoglobulin (Ig) genes plays a key role in antibody mediated immun...
Somatic hypermutation of immunoglobulin genes is an important contributor to antibody diversity. Lac...
To determine whether DNA polymerase plays a role in the hypermutation of immunoglobulin variable gen...
B cells produce a diverse array of antibody specificities that are of low affinity during the initia...
During somatic hypermutation (SHM) of antibody variable (V) region genes, activation-induced cytidin...
AbstractIg somatic mutations would be introduced by a polymerase (pol) while repairing DNA outside m...
International audienceMutations at A/T bases within immunoglobulin genes have been shown to be gener...
The DNA sequence data of the somatic hypermutation (SHM) field published since 1984 has been critica...
International audienceSomatic hypermutation (SHM) of immunoglobulin (Ig) genes is a B cell specific ...
Somatic hypermutation of Ig genes is initiated by transcription-coupled cytidine deamination in Ig l...
A¤nity maturation of the humoral immune response is based on the ability of immunoglobulin variable ...
AbstractAs the rate of Ig gene hypermutation approximates the level of nucleotide discrimination of ...
AbstractSomatic hypermutation (SHM) of immunoglobulin (Ig) genes appears to involve the generation o...
<p>DNA polymerase (pol) η is a specialized error-prone polymerase with at least two quite different ...
The history and current development of the reverse transcriptase model of somatic hypermutation (RT-...
Somatic hypermutation (SHM) of immunoglobulin (Ig) genes plays a key role in antibody mediated immun...
Somatic hypermutation of immunoglobulin genes is an important contributor to antibody diversity. Lac...
To determine whether DNA polymerase plays a role in the hypermutation of immunoglobulin variable gen...