Therapy Related Mast Cell Leukemia Presenting In A Pediatric Patient:

Mastocytosis is a heterogenous group of disorders caused by the proliferation and accumulation of neoplastic mast cells. In the pediatric population, mastocytosis is typically limited to the skin (cutaneous mastocytosis) and follows an indolent clinical course with excellent prognosis. More aggressive disorders, such as mast cell leukemia and myelomastocytic leukemia, most commonly present in adult patients, with only a few cases reported in the pediatric population. We present a rare case of mast cell leukemia with myelodysplastic features, arising post chemotherapy in a 13 year old female with a history of rhabdomyosarcoma. The patient initially presented with sore throat, body aches, upset stomach and fever. A complete blood count and peripheral smear revealed thrombocytopenia and abnormal cells concerning for acute promyelocytic leukemia. Computed tomography reporte