Peripheral Dysostosis

drome (cerebral gigantism) with peripheral dysostosis. A girl had short stumpy hands and feet due to osseous dystrophy; in other respects she showed all the main and many of the minor features of Sotos ' syndrome during infancy. Then she was on the 97th centile for height, but she grew to be a woman on the 10th centile. Menarche was at 123 years; growth in height stopped before 141 though epiphysial fusion had not occurred; educational difficulties were still being fought at 18 years but she was well adjusted and happy. This case is presented because (1) the combina-tion of cerebral gigantism and gross manupedal dysostosis is unusual, perhaps unique; and (2) growth has been followed from infancy into adult life. Case Report IThe patient was a girl born in 1952, only child of non-consanguineous parents; her father was an epilepti