The Correlation between LVH, LV Function and 24-hour Ambulatory Blood Pressure Monitoring in Patients with Newly Diagnosed Hypertension

Background：Left ventricular hypertrophy is one of the major cardiovascular risk factors. So it is generally thought to be a predictor of complication and prognosis of hypertension. The 24-hour noninvasive ambulatory blood pressure monitoring(ABP) has been shown to be superior to office BP in predicting target organ involvement in patients with hypertension and assessing antihypertensive therapy. To determine the correlation between blood pressure and left ventricular hypertrophy in patients with newly diagnosed systemic hypertension, we evaluate blood pressure by 24-hour ABP, office BP and echocardiographic parameters of left ventricular hypertrophy. Methods：From January 1995 to September 1995, in 22 patients with untreated essential hypert-ension who were diagnosed recently(within 1 month). They were studied by 24-hour noninvasive ambulatory blood pressure monitoring and cross sectional, M-mode and pulsed Doppler echocardio-graphy for examining the relation between ABP and echocardiographic parameters. In the present study, we divided the patients by two groups；white-coat hypertensive group and sustained hypertensive group. Results： 1) Among the 22 patients who were diagnosed by office blood pressure, the white-coat hypertension was in 7 cases(31.8%) and sustained hypertension was 15 cases(68.2%). 2) In sustained hypertensive group, LV mass, LV mass index and relative posterior septal wall thickness were significantly increased compared with white-coat hypertensive group. 3) 24-hour ABP and systolic BP and loading % were significantly correlated with relative posterior septal wall thickness(p<0.05). Conclusion：In patients with newly diagnosed hypertension(especially with sustained hyper