Systematic Reviews and Meta- and Pooled Analyses The Contribution of Genomic Research to Explaining Racial Disparities in Cardiovascular Disease: A Systematic Review

After nearly a decade of genome-wide association studies, no assessment has yet been made of their contribu-tion toward an explanation of the most prominent racial health disparities observed at the population level. We examined populations of African and European ancestry and focused on cardiovascular diseases, which are col-lectively the largest contributor to the racial mortality gap. We conducted a systematic search for review articles and meta-analyses published in 2007–2013 in which genetic data from both populations were available. We identified 68 articles relevant to this question; however, few reported significant associations in both racial groups, with just 3 variants meeting study-specific significance criteria. For most outcomes, there were too few estimates for quanti-tative summarization, but when summarization was possible, racial group did not contribute to heterogeneity. Most associations reported from genome-wide searches were small, difficult to replicate, and in no consistent direction that favored one racial group or another. Although the substantial investment in this technology might have pro-duced clinical advances, it has thus far made little or no contribution to our understanding of population-level racial health disparities in cardiovascular disease. cardiovascular disease; continental population groups; genomics; health-care disparities; systematic review Abbreviations: CVD, cardiovascular disease; GWAS, genome-wide association study; SNP, single nucleotide polymorphism. Epidemiologic research seeks to describe and explain pat