Long-term Oral Anticoagulant Therapy

normal VIII-related protein, as described by Holmberg and Nilsson (1973). The three patients to whom cryo-precipitate was given all showed a post-infusion correction of Ristocetin aggre-gation, although the response of factor VIII and VIII-related protein varied in each case. To the standard definition of classical von Willebrand's disease, it is now possible to add abnormal Ristocetin-induced aggregation and reduced or absent levels of factor-VIII-related protein. However, more variants of this disorder, two of which have been discussed in this paper, are likely to be described